- A Case of MELAS Syndrome Manifested by Insulin-deficient Diabetes Mellitus.
-
Hee Seog Jeong, Ji Young Kang, Hyun Kim, Kyu Ho Lee, Dal Sic Lee, Guan Yong Choi, Tae Geun Oh, Hyen Jeong Jeon
-
J Korean Endocr Soc. 2008;23(6):444-449. Published online December 1, 2008
-
DOI: https://doi.org/10.3803/jkes.2008.23.6.444
-
-
2,009
View
-
48
Download
-
1
Crossref
-
 Abstract
 PDF
- MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system.
-
Citations
Citations to this article as recorded by  - Characteristic Neuroimaging Findings in a Patient with Acute Metabolic Encephalopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome Distinguishable from that of Acute Ischemic Stroke
Hyodong Kim, Jung-ju Lee, Byung-kun Kim, Ohyun Kwon, Jong-moo Park, Kyusik Kang, Woong-woo Lee
Journal of the Korean Neurological Association.2020; 38(1): 37. CrossRef
- Imaging of Hyperparathyroidism.
-
Sung Soo Koong, Tae Geun Oh
-
J Korean Endocr Soc. 1998;13(3):308-312. Published online January 1, 2001
-
-
-
Abstract
PDF
- No abstract available.
- Gene Therapy.
-
Seung Taik Kim, Tae Geun Oh
-
J Korean Endocr Soc. 1998;13(1):1-11. Published online January 1, 2001
-
-
-
Abstract
PDF
- No abstract available.
- Insulin Resistance, Body Fat Distribution, and Sex Hormones in Healthy Men and Premenopausal Women.
-
Seong Yeon Kim, Kyung Soo Park, Bo Youn Cho, Hong Kyu Lee, Chan Soo Shin, Chang Soon Koh, Tae Geun Oh, Woon Bae Kim
-
J Korean Endocr Soc. 1994;9(4):366-374. Published online November 6, 2019
-
-
-
Abstract
PDF
- It is well known that obesity central obesity is associated with insulin resistance and some studies reported that sex hormones were associated with insulin resistance. Recently, low levels of sex-hormone binding globulin(SHBG), an indirect index of androgenicity, have been observed to predict the development of non-insulin dependent diabetes mellitus(NIDDM) in women and SHBG has been proposed as a marker for insulin resistance. In contrast to findings in women, decreased SHBG did not predict the occurrence of NIDDM in men, so it is suggested that sex hormones may have a different role for insulin resistance between men and women. To investigate the difference of the associations among the body fat distribution, sex hormone and insulin sensitivity index in men and women, we measured body-mass index(BMI) and waist to hip circumference ratio(WHR) and concentrations serum SHBG, total testosterone, free testosterone, and dehydroepiandrosterone sulfate(DHEA-S) concentrations in 29 healthy adults(men:19, women:10) who showed normal glucose tolerance. Insulin sensitivity index(M/I) was measured by euglycemic hyperinsulinemic clamp. There were no differences in age, BMI, fasting plasma glucose, insulin and free fatty acid levels between men and women. WHR of men is higher than that of women(0.82+-0.01 vs. 0.73+-0.01, p=0.002). Insulin sensitivity index(M/I) is similar in men and women(7.80+-0.71 mg/kg/min/uU/ml X 100 vs. 9.74+-0.89 mg/kg/min/uU/ml X 100, p=0.196).In Pearson's correlation, M/I was significantly correlated with BMI(r=-0.69, p<0.01) and WHR(r=-0.68, p<0.01) in men and DHEA-S(r=-0.68, p<0.05) and SHBG(r=0.61, p=0.056) concentrations in women.In multiple regression analysis, M/I had the most significant association with BMI(R^2=0.484, beta=-0.696, p<0.001) in men and DHEA-S(R^2=0.471, beta=-0.686, p<0.05) concentration in women.Conclusively, we found that sex hormones were significantly associated with insulin resistance and the effects of sex hormones on insulin resistance may be different in men and women.
- Effect of Antiliyolytic Agents on Glueose Metabolism in Thyrotoxic Patients.
-
Seong Yeon Kim, Kyung Soo Park, Bo Youn Cho, Hong Kyu Lee, Chan Soo Shin, Chang Soon Koh, Hun Ki Min, Tae Geun Oh, Chul Hee Kim, Moon Kyu Lee, Jong Ho Ahn, Kee Up Lee
-
J Korean Endocr Soc. 1994;9(4):325-331. Published online November 6, 2019
-
-
-
Abstract
PDF
- Decreased glucose tolerance is often found in patients with thyrotoxicosis but the pathogenetic mechanisms are poorly understood. Since the concentrations of free fatty acid are usually elevated due to increased lipolysis in thyrotoxicosis, the preferential oxidation of the free fatty acids may explain the decreased glucose tolerance in hyperthyroidism. The aim of this study was to investigate whether lowering plasma free fatty acid(FFA) by acipimox, a long-acting antilipolytic agent, could affect glucose metabolism in thyrotoxicosis. We performed intravenous glucose tolerance test with acipimox or placebo in 6 untreated thyrotoxicmen and 6 age-and body mass index(BMI)-matched controls. The following results were obtained.1) The basal plasma FFA concentration in thyrotoxic patients were significantly higher than those in controls(997.0+-303.4 uEq/L vs. 290.5+-169.1 uEq/L; p<0.01). 2) Plasma FFA concentrations decreased rapidly with acipimox ingestion in both controls and thyrotoxic patients.3) Plasma glucose concentrations were significantly lower with acipimox ingestion than with placebo in thyrotoxic patients from 17min after intravenous glucose load and to the end of the study.4) Plasma insulin concentrations in thyrotoxic patients with acipimox ingestion were higher at 5, 7 min after iv glucose load.5) In thyrotoxic patients, glucose disappearance rate(K_glucose) in acipimox treatment was significantly higher than that in placebo treatment(2.44+-0.84 vs. 1.58+-0.37;p<0.05). 6) K_glucose values were inversely correlated with basal FFA concentrations(r=-0.58, p<0.05). In summary, in thyrotoxic patients with elevated plasma FFA levels, acipimox lowered plasma FFA, which in turn improved glucose tolerance.
- Cell density dependence of growth characteristics of rat thyroid cells(FRTL-5) stimulated by TSH and IGF-I.
-
Dong Soo Lee, Jae Joon Koh, Jong Ho Ahn, Tae Geun Oh, Bo Youn Cho, Hong Kyu Lee, Chang Soon Koh
-
J Korean Endocr Soc. 1993;8(3):287-295. Published online January 1, 2001
-
-
-
Abstract
PDF
- No abstract available.
- Combined estrogen-progesterone(Divina@) treatment in postmenopausal women with special reference to serum lipoprotein patterns.
-
Min Seon Kim, Tae Geun Oh, Kyung Soo Ko, Kyong Soo Park, Seong Yeon Kim, Hong Kyu Lee, Chang Soon Koh, Hun Ki Min, Hak Chul Jang, Yong Ki Min, In Kwon Han
-
J Korean Endocr Soc. 1992;7(3):267-272. Published online January 1, 2001
-
-
-
Abstract
PDF
- No abstract available.
|
KES
